STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)    
Predicted Functional Partners:
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.996
TRADD
TNFRSF1A associated via death domain.
    
 0.996
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.995
LTA
Lymphotoxin alpha; Belongs to the tumor necrosis factor family.
    
 0.995
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.994
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.992
CYLD
CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.
    
 0.990
TRAF1
TNF receptor-associated factor.
    
 0.990
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.987
FADD
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
   
 0.986
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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