node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHUK | CYLD | ENSSTOP00000014691 | ENSSTOP00000009149 | Component of inhibitor of nuclear factor kappa B kinase complex. | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | 0.860 |
CHUK | FADD | ENSSTOP00000014691 | ENSSTOP00000024623 | Component of inhibitor of nuclear factor kappa B kinase complex. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.706 |
CHUK | IKBKB | ENSSTOP00000014691 | ENSSTOP00000005204 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.996 |
CHUK | IKBKG | ENSSTOP00000014691 | ENSSTOP00000026959 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.996 |
CHUK | RIPK1 | ENSSTOP00000014691 | ENSSTOP00000001385 | Component of inhibitor of nuclear factor kappa B kinase complex. | Receptor interacting serine/threonine kinase 1. | 0.958 |
CHUK | TNFRSF1A | ENSSTOP00000014691 | ENSSTOP00000009024 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNF receptor superfamily member 1A. | 0.992 |
CHUK | TRADD | ENSSTOP00000014691 | ENSSTOP00000010191 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNFRSF1A associated via death domain. | 0.927 |
CHUK | TRAF1 | ENSSTOP00000014691 | ENSSTOP00000021806 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNF receptor-associated factor. | 0.925 |
CHUK | TRAF2 | ENSSTOP00000014691 | ENSSTOP00000010851 | Component of inhibitor of nuclear factor kappa B kinase complex. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.979 |
CYLD | CHUK | ENSSTOP00000009149 | ENSSTOP00000014691 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.860 |
CYLD | FADD | ENSSTOP00000009149 | ENSSTOP00000024623 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.837 |
CYLD | IKBKB | ENSSTOP00000009149 | ENSSTOP00000005204 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.847 |
CYLD | IKBKG | ENSSTOP00000009149 | ENSSTOP00000026959 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.983 |
CYLD | RIPK1 | ENSSTOP00000009149 | ENSSTOP00000001385 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | Receptor interacting serine/threonine kinase 1. | 0.984 |
CYLD | TNFRSF1A | ENSSTOP00000009149 | ENSSTOP00000009024 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | TNF receptor superfamily member 1A. | 0.990 |
CYLD | TRADD | ENSSTOP00000009149 | ENSSTOP00000010191 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | TNFRSF1A associated via death domain. | 0.879 |
CYLD | TRAF1 | ENSSTOP00000009149 | ENSSTOP00000021806 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | TNF receptor-associated factor. | 0.888 |
CYLD | TRAF2 | ENSSTOP00000009149 | ENSSTOP00000010851 | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.940 |
FADD | CHUK | ENSSTOP00000024623 | ENSSTOP00000014691 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.706 |
FADD | CYLD | ENSSTOP00000024623 | ENSSTOP00000009149 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. | 0.837 |