STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLF10Kruppel like factor 10. (480 aa)    
Predicted Functional Partners:
NAB2
NGFI-A binding protein 2.
    
 0.703
SIN3A
SIN3 transcription regulator family member A.
    
 
 0.662
FOXP3
Forkhead box P3.
    
 
 0.573
SIN3B
SIN3 transcription regulator family member B.
    
 
 0.520
I3MHF1_ICTTR
Uncharacterized protein.
    
  0.501
BARD1
BRCA1 associated RING domain 1.
    
  0.490
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.486
SP1
Sp1 transcription factor.
    
 
0.479
GTF3C3
General transcription factor IIIC subunit 3.
    
 0.474
YTHDC2
YTH domain containing 2.
    
  0.474
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.