node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E2F1 | NDN | ENSSTOP00000002445 | ENSSTOP00000016251 | E2F transcription factor 1. | Necdin, MAGE family member. | 0.699 |
E2F1 | TP53 | ENSSTOP00000002445 | ENSSTOP00000019678 | E2F transcription factor 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.730 |
EID3 | NDN | ENSSTOP00000023416 | ENSSTOP00000016251 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Necdin, MAGE family member. | 0.827 |
EID3 | NSMCE1 | ENSSTOP00000023416 | ENSSTOP00000017143 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | NSE1 homolog, SMC5-SMC6 complex component. | 0.992 |
EID3 | NSMCE2 | ENSSTOP00000023416 | ENSSTOP00000016944 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | 0.991 |
EID3 | SMC1B | ENSSTOP00000023416 | ENSSTOP00000001064 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein. | 0.877 |
EID3 | SMC3 | ENSSTOP00000023416 | ENSSTOP00000032666 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes 3. | 0.919 |
EID3 | SMC5 | ENSSTOP00000023416 | ENSSTOP00000028936 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes 5. | 0.993 |
EID3 | SMC6 | ENSSTOP00000023416 | ENSSTOP00000012504 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes 6. | 0.991 |
NDN | E2F1 | ENSSTOP00000016251 | ENSSTOP00000002445 | Necdin, MAGE family member. | E2F transcription factor 1. | 0.699 |
NDN | EID3 | ENSSTOP00000016251 | ENSSTOP00000023416 | Necdin, MAGE family member. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.827 |
NDN | NSMCE1 | ENSSTOP00000016251 | ENSSTOP00000017143 | Necdin, MAGE family member. | NSE1 homolog, SMC5-SMC6 complex component. | 0.894 |
NDN | NSMCE2 | ENSSTOP00000016251 | ENSSTOP00000016944 | Necdin, MAGE family member. | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | 0.882 |
NDN | NSMCE4A | ENSSTOP00000016251 | ENSSTOP00000009968 | Necdin, MAGE family member. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.827 |
NDN | SMC1B | ENSSTOP00000016251 | ENSSTOP00000001064 | Necdin, MAGE family member. | Structural maintenance of chromosomes protein. | 0.620 |
NDN | SMC3 | ENSSTOP00000016251 | ENSSTOP00000032666 | Necdin, MAGE family member. | Structural maintenance of chromosomes 3. | 0.671 |
NDN | SMC5 | ENSSTOP00000016251 | ENSSTOP00000028936 | Necdin, MAGE family member. | Structural maintenance of chromosomes 5. | 0.885 |
NDN | SMC6 | ENSSTOP00000016251 | ENSSTOP00000012504 | Necdin, MAGE family member. | Structural maintenance of chromosomes 6. | 0.885 |
NDN | TP53 | ENSSTOP00000016251 | ENSSTOP00000019678 | Necdin, MAGE family member. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.892 |
NSMCE1 | EID3 | ENSSTOP00000017143 | ENSSTOP00000023416 | NSE1 homolog, SMC5-SMC6 complex component. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.992 |