node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKL_0432 | clpB | CKL_0432 | CKL_2702 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.471 |
CKL_0432 | dnaJ | CKL_0432 | CKL_0903 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are r [...] | 0.802 |
CKL_0432 | dnaK5 | CKL_0432 | CKL_0902 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | DnaK5; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.503 |
CKL_0432 | groL | CKL_0432 | CKL_0464 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.779 |
CKL_0432 | groS | CKL_0432 | CKL_0463 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.783 |
CKL_0432 | grpE | CKL_0432 | CKL_0901 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interacti [...] | 0.676 |
CKL_0432 | hrcA | CKL_0432 | CKL_0900 | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.447 |
CKL_2384 | clpB | CKL_2384 | CKL_2702 | Chaperone-related protein. | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.580 |
CKL_2384 | dnaJ | CKL_2384 | CKL_0903 | Chaperone-related protein. | DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are r [...] | 0.866 |
CKL_2384 | dnaK5 | CKL_2384 | CKL_0902 | Chaperone-related protein. | DnaK5; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.791 |
CKL_2384 | groL | CKL_2384 | CKL_0464 | Chaperone-related protein. | GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.884 |
CKL_2384 | groS | CKL_2384 | CKL_0463 | Chaperone-related protein. | GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.786 |
CKL_2384 | grpE | CKL_2384 | CKL_0901 | Chaperone-related protein. | GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interacti [...] | 0.761 |
clpB | CKL_0432 | CKL_2702 | CKL_0432 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | CoA-disulfide reductase-related protein; Belongs to the sulfur carrier protein TusA family. | 0.471 |
clpB | CKL_2384 | CKL_2702 | CKL_2384 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone-related protein. | 0.580 |
clpB | clpP | CKL_2702 | CKL_3351 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.887 |
clpB | dnaJ | CKL_2702 | CKL_0903 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are r [...] | 0.842 |
clpB | dnaK5 | CKL_2702 | CKL_0902 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaK5; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.932 |
clpB | groL | CKL_2702 | CKL_0464 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.877 |
clpB | groS | CKL_2702 | CKL_0463 | ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.855 |