node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKL_0144 | CKL_0486 | CKL_0144 | CKL_0486 | Transcriptional regulator. | GMP synthase. | 0.819 |
CKL_0144 | add | CKL_0144 | CKL_0833 | Transcriptional regulator. | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | 0.544 |
CKL_0144 | guaA | CKL_0144 | CKL_0466 | Transcriptional regulator. | GuaA; Catalyzes the synthesis of GMP from XMP. | 0.819 |
CKL_0144 | guaB | CKL_0144 | CKL_0465 | Transcriptional regulator. | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.592 |
CKL_0144 | purA | CKL_0144 | CKL_0087 | Transcriptional regulator. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.577 |
CKL_0327 | add | CKL_0327 | CKL_0833 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | 0.902 |
CKL_0327 | apt | CKL_0327 | CKL_3132 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.900 |
CKL_0327 | cdd | CKL_0327 | CKL_0915 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Cdd; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.900 |
CKL_0327 | punA | CKL_0327 | CKL_1608 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | PunA; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.900 |
CKL_0327 | surE | CKL_0327 | CKL_0997 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
CKL_0486 | CKL_0144 | CKL_0486 | CKL_0144 | GMP synthase. | Transcriptional regulator. | 0.819 |
CKL_0486 | add | CKL_0486 | CKL_0833 | GMP synthase. | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | 0.628 |
CKL_0486 | apt | CKL_0486 | CKL_3132 | GMP synthase. | Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.826 |
CKL_0486 | guaB | CKL_0486 | CKL_0465 | GMP synthase. | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.998 |
CKL_0486 | punA | CKL_0486 | CKL_1608 | GMP synthase. | PunA; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.627 |
CKL_0486 | purA | CKL_0486 | CKL_0087 | GMP synthase. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.808 |
CKL_0486 | surE | CKL_0486 | CKL_0997 | GMP synthase. | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.545 |
add | CKL_0144 | CKL_0833 | CKL_0144 | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | Transcriptional regulator. | 0.544 |
add | CKL_0327 | CKL_0833 | CKL_0327 | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | 0.902 |
add | CKL_0486 | CKL_0833 | CKL_0486 | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | GMP synthase. | 0.628 |