node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | folD | CKL_0440 | CKL_0442 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.999 |
fhs | gcvPB | CKL_0440 | CKL_1771 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.472 |
fhs | gcvT | CKL_0440 | CKL_1774 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.954 |
fhs | glyA | CKL_0440 | CKL_1284 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.991 |
fhs | metH1 | CKL_0440 | CKL_0976 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | MetH1; Predicted methionine synthase. | 0.978 |
fhs | metH2 | CKL_0440 | CKL_1762 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | MetH2; Predicted methionine synthase. | 0.981 |
fhs | purH | CKL_0440 | CKL_2684 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PurH; Predicted bifunctional purine biosynthesis protein purH. | 0.966 |
fhs | purL | CKL_0440 | CKL_1286 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PurL; Predicted phosphoribosylformylglycinamidine synthase. | 0.975 |
fhs | purN | CKL_0440 | CKL_2685 | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
folD | fhs | CKL_0442 | CKL_0440 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Fhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.999 |
folD | gcvPB | CKL_0442 | CKL_1771 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.603 |
folD | gcvT | CKL_0442 | CKL_1774 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.961 |
folD | glyA | CKL_0442 | CKL_1284 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.992 |
folD | metH1 | CKL_0442 | CKL_0976 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | MetH1; Predicted methionine synthase. | 0.700 |
folD | metH2 | CKL_0442 | CKL_1762 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | MetH2; Predicted methionine synthase. | 0.968 |
folD | purH | CKL_0442 | CKL_2684 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PurH; Predicted bifunctional purine biosynthesis protein purH. | 0.956 |
folD | purL | CKL_0442 | CKL_1286 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PurL; Predicted phosphoribosylformylglycinamidine synthase. | 0.912 |
folD | purN | CKL_0442 | CKL_2685 | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
gcvPA | gcvPB | CKL_1772 | CKL_1771 | GcvPA; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
gcvPA | gcvT | CKL_1772 | CKL_1774 | GcvPA; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |