node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKL_1646 | dinB | CKL_1646 | CKL_3439 | Transcriptional regulator. | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.741 |
CKL_1646 | recA | CKL_1646 | CKL_1445 | Transcriptional regulator. | RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.910 |
CKL_1734 | dinB | CKL_1734 | CKL_3439 | Predicted NRPS adenylation domain. | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.541 |
CKL_1734 | dnaN | CKL_1734 | CKL_0002 | Predicted NRPS adenylation domain. | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | 0.481 |
CKL_1734 | polA | CKL_1734 | CKL_0669 | Predicted NRPS adenylation domain. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.837 |
CKL_1734 | recA | CKL_1734 | CKL_1445 | Predicted NRPS adenylation domain. | RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.886 |
CKL_1734 | recX | CKL_1734 | CKL_3329 | Predicted NRPS adenylation domain. | Predicted regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.475 |
CKL_1765 | dinB | CKL_1765 | CKL_3439 | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.825 |
CKL_1765 | polA | CKL_1765 | CKL_0669 | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.750 |
CKL_1765 | recA | CKL_1765 | CKL_1445 | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.968 |
CKL_1765 | recX | CKL_1765 | CKL_3329 | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | Predicted regulatory protein; Modulates RecA activity; Belongs to the RecX family. | 0.531 |
CKL_1765 | sbcD | CKL_1765 | CKL_0122 | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | Predicted exonuclease, sbcD related; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.475 |
dinB | CKL_1646 | CKL_3439 | CKL_1646 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Transcriptional regulator. | 0.741 |
dinB | CKL_1734 | CKL_3439 | CKL_1734 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Predicted NRPS adenylation domain. | 0.541 |
dinB | CKL_1765 | CKL_3439 | CKL_1765 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. | 0.825 |
dinB | dnaN | CKL_3439 | CKL_0002 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for [...] | 0.941 |
dinB | lexA | CKL_3439 | CKL_1579 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.882 |
dinB | polA | CKL_3439 | CKL_0669 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.763 |
dinB | recA | CKL_3439 | CKL_1445 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.901 |
dinB | sbcD | CKL_3439 | CKL_0122 | DinB; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Predicted exonuclease, sbcD related; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.407 |