node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
pyrB | pyrC | CKL_3361 | CKL_3359 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrD2 | CKL_3361 | CKL_3356 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrD2; Catalyzes the conversion of dihydroorotate to orotate. | 0.991 |
pyrB | pyrE | CKL_3361 | CKL_3355 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.982 |
pyrB | pyrF | CKL_3361 | CKL_3358 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrF; Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.994 |
pyrB | pyrH | CKL_3361 | CKL_1419 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.742 |
pyrB | pyrI | CKL_3361 | CKL_3360 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrI; Aspartate carbamoyltransferase regulatory chain. | 0.999 |
pyrB | pyrK | CKL_3361 | CKL_3357 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrK; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.976 |
pyrB | pyrR | CKL_3361 | CKL_1201 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.991 |
pyrB | surE | CKL_3361 | CKL_0997 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.590 |
pyrB | upp | CKL_3361 | CKL_3702 | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.630 |
pyrC | pyrB | CKL_3359 | CKL_3361 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
pyrC | pyrD2 | CKL_3359 | CKL_3356 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrD2; Catalyzes the conversion of dihydroorotate to orotate. | 0.999 |
pyrC | pyrE | CKL_3359 | CKL_3355 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.980 |
pyrC | pyrF | CKL_3359 | CKL_3358 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrF; Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.962 |
pyrC | pyrH | CKL_3359 | CKL_1419 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.545 |
pyrC | pyrI | CKL_3359 | CKL_3360 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrI; Aspartate carbamoyltransferase regulatory chain. | 0.979 |
pyrC | pyrK | CKL_3359 | CKL_3357 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrK; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.998 |
pyrC | pyrR | CKL_3359 | CKL_1201 | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.980 |
pyrD2 | pyrB | CKL_3356 | CKL_3361 | PyrD2; Catalyzes the conversion of dihydroorotate to orotate. | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.991 |
pyrD2 | pyrC | CKL_3356 | CKL_3359 | PyrD2; Catalyzes the conversion of dihydroorotate to orotate. | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |