node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD65830.1 | ACD66568.1 | SYO3AOP1_0185 | SYO3AOP1_0945 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.434 |
ACD65830.1 | ACD67097.1 | SYO3AOP1_0185 | SYO3AOP1_1495 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aae:aq_2109 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.873 |
ACD65830.1 | hemA | SYO3AOP1_0185 | SYO3AOP1_0208 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.722 |
ACD65830.1 | hemC | SYO3AOP1_0185 | SYO3AOP1_0690 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
ACD65830.1 | hemE | SYO3AOP1_0185 | SYO3AOP1_1089 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.930 |
ACD65830.1 | hemL | SYO3AOP1_0185 | SYO3AOP1_1432 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: bsu:BSU28120 glutamate-1-semialdehyde aminotransferase. | 0.462 |
ACD66568.1 | ACD65830.1 | SYO3AOP1_0945 | SYO3AOP1_0185 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.434 |
ACD66568.1 | ACD66770.1 | SYO3AOP1_0945 | SYO3AOP1_1158 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: fnu:FN0149 malonyl-CoA-[acyl-carrier-protein] transacylase. | 0.554 |
ACD66568.1 | ACD67097.1 | SYO3AOP1_0945 | SYO3AOP1_1495 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aae:aq_2109 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.572 |
ACD66568.1 | guaA | SYO3AOP1_0945 | SYO3AOP1_1628 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.571 |
ACD66568.1 | hemA | SYO3AOP1_0945 | SYO3AOP1_0208 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.429 |
ACD66568.1 | hemC | SYO3AOP1_0945 | SYO3AOP1_0690 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.414 |
ACD66568.1 | hemL | SYO3AOP1_0945 | SYO3AOP1_1432 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: bsu:BSU28120 glutamate-1-semialdehyde aminotransferase. | 0.538 |
ACD66568.1 | nrdR | SYO3AOP1_0945 | SYO3AOP1_1431 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.662 |
ACD66568.1 | thiE | SYO3AOP1_0945 | SYO3AOP1_0005 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.414 |
ACD66770.1 | ACD66568.1 | SYO3AOP1_1158 | SYO3AOP1_0945 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: fnu:FN0149 malonyl-CoA-[acyl-carrier-protein] transacylase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.554 |
ACD66770.1 | ACD67097.1 | SYO3AOP1_1158 | SYO3AOP1_1495 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: fnu:FN0149 malonyl-CoA-[acyl-carrier-protein] transacylase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aae:aq_2109 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.496 |
ACD66770.1 | guaA | SYO3AOP1_1158 | SYO3AOP1_1628 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: fnu:FN0149 malonyl-CoA-[acyl-carrier-protein] transacylase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.453 |
ACD66770.1 | hemL | SYO3AOP1_1158 | SYO3AOP1_1432 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: fnu:FN0149 malonyl-CoA-[acyl-carrier-protein] transacylase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: bsu:BSU28120 glutamate-1-semialdehyde aminotransferase. | 0.828 |
ACD67097.1 | ACD65830.1 | SYO3AOP1_1495 | SYO3AOP1_0185 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aae:aq_2109 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.873 |