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nth protein (Nitrosopumilus maritimus) - STRING interaction network
"nth" - Endonuclease III in Nitrosopumilus maritimus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (218 aa)    
Predicted Functional Partners:
Nmar_0340
PFAM- ExsB family protein; PP-loop domain protein; KEGG- dsy-DSY3982 hypothetical protein (265 aa)
            0.804
Nmar_0546
Aminotransferase; PFAM- Chorismate mutase; aminotransferase class I and II; KEGG- tpt-Tpet_1516 aminotransferase, class I and II (456 aa)
 
     
  0.643
purD
KEGG- cbd-COXBU7E912_1753 phosphoribosylamine--glycine ligase; TIGRFAM- phosphoribosylamine--glycine ligase; PFAM- phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; ATP-grasp domain protein; Belongs to the GARS family (421 aa)
   
   
  0.643
Nmar_1008
D-alanine--D-alanine ligase; PFAM- peptidase M20; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; RimK domain protein ATP-grasp; KEGG- amt-Amet_3744 D-alanine--D-alanine ligase domain protein (743 aa)
 
          0.640
Nmar_1540
HhH-GPD family protein; PFAM- helix-hairpin-helix motif; HhH-GPD family protein; 8-oxoguanine DNA glycosylase domain protein; KEGG- csc-Csac_1515 8-oxoguanine DNA glycosylase domain protein (287 aa)
   
 
  0.636
Nmar_0054
PFAM- protein of unknown function DUF126; KEGG- mst-Msp_0225 hypothetical protein (128 aa)
              0.625
Nmar_0053
PFAM- protein of unknown function DUF521; KEGG- mae-Maeo_1036 protein of unknown function DUF521 (384 aa)
              0.625
Nmar_1756
PFAM- Transcription factor TFIIS; SMART- DNA-directed RNA polymerase, M15 kDa subunit; KEGG- mja-MJ1148 DNA-directed RNA polymerase subunit M; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family (105 aa)
       
 
  0.607
nfo
Probable endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (279 aa)
   
 
  0.600
fen
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (340 aa)
   
 
  0.598
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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