STRINGSTRING
aroA protein (Nitrosopumilus maritimus) - STRING interaction network
"aroA" - 3-phosphoshikimate 1-carboxyvinyltransferase in Nitrosopumilus maritimus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate (422 aa)    
Predicted Functional Partners:
aroE
Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) (273 aa)
   
  0.998
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system (365 aa)
 
 
  0.994
aroK
TIGRFAM- shikimate kinase; PFAM- GHMP kinase; KEGG- mae-Maeo_0247 shikimate kinase (284 aa)
 
   
    0.993
aroD
3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate; Belongs to the type-I 3-dehydroquinase family (223 aa)
   
  0.990
Nmar_0546
Aminotransferase; PFAM- Chorismate mutase; aminotransferase class I and II; KEGG- tpt-Tpet_1516 aminotransferase, class I and II (456 aa)
         
  0.965
aroB'
3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis (353 aa)
 
 
 
  0.898
Nmar_0545
PFAM- Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG- mba-Mbar_A0924 prephenate dehydrogenase (283 aa)
 
     
  0.864
Nmar_1567
PFAM- prephenate dehydratase; amino acid-binding ACT domain protein; KEGG- det-DET0461 chorismate mutase / prephenate dehydratase (271 aa)
 
   
  0.783
aroA'
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids (260 aa)
              0.723
Nmar_0299
PFAM- ribulose-phosphate 3-epimerase; Transketolase domain protein; KEGG- pth-PTH_2750 transketolase, N-terminal subunit (555 aa)
              0.571
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
Server load: low (14%) [HD]