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fen protein (Nitrosopumilus maritimus) - STRING interaction network
"fen" - Flap endonuclease 1 in Nitrosopumilus maritimus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fenFlap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (340 aa)    
Predicted Functional Partners:
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (248 aa)
   
 
  0.992
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (588 aa)
 
 
  0.919
Nmar_0087
RecA/RadA recombinase-like protein; KEGG- tac-Ta1104 probable DNA repair protein Rad51 (RadA) (217 aa)
 
 
  0.914
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids; Belongs to the RNase HII family (205 aa)
 
 
  0.856
priS
DNA primase small subunit PriS; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (373 aa)
   
   
  0.848
Nmar_0270
PFAM- AAA ATPase central domain protein; SMART- AAA ATPase; KEGG- mth-MTH240 replication factor C, large subunit (385 aa)
 
 
  0.830
Nmar_0299
PFAM- ribulose-phosphate 3-epimerase; Transketolase domain protein; KEGG- pth-PTH_2750 transketolase, N-terminal subunit (555 aa)
   
   
  0.808
dnaG
DNA primase DnaG; SMART- Toprim sub domain protein; KEGG- sso-SSO0079 Bacterial-like DNA primase (380 aa)
 
   
  0.797
top6A
Type 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family (370 aa)
   
 
  0.782
Nmar_0948
PFAM- DNA polymerase B exonuclease; DNA polymerase B region; SMART- DNA-directed DNA polymerase B; KEGG- tpe-Tpen_0298 DNA polymerase B region (852 aa)
 
 
  0.780
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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