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guaB protein (Nitrosopumilus maritimus) - STRING interaction network
"guaB" - Inosine-5'-monophosphate dehydrogenase in Nitrosopumilus maritimus
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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guaBInosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (476 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (507 aa)
 
  0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (333 aa)
 
 
  0.985
Nmar_0068
PFAM- glutamine amidotransferase class-I; KEGG- pto-PTO1342 GMP synthase subunit A (180 aa)
 
  0.984
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (533 aa)
   
 
  0.965
Nmar_1530
TIGRFAM- non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM- Ham1 family protein; KEGG- mka-MK1594 xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family (188 aa)
   
  0.959
pckA
Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (499 aa)
   
 
    0.904
Nmar_1568
annotation not available (155 aa)
              0.840
purL
Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought t [...] (721 aa)
   
   
  0.814
purM
KEGG- msi-Msm_1039 phosphoribosylformylglycinamidine cyclo-ligase (AirS), PurM; TIGRFAM- phosphoribosylformylglycinamidine cyclo-ligase; PFAM- AIR synthase related protein; AIR synthase related protein domain protein (340 aa)
 
   
  0.798
Nmar_0323
TIGRFAM- glucosamine--fructose-6-phosphate aminotransferase, isomerizing; PFAM- glutamine amidotransferase class-II; sugar isomerase (SIS); KEGG- pab-PAB2201 glucosamine--fructose-6-phosphate aminotransferase (586 aa)
 
   
  0.797
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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