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tmk protein (Nitrosopumilus maritimus) - STRING interaction network
"tmk" - PFAM: thymidylate kinase in Nitrosopumilus maritimus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
tmkPFAM- thymidylate kinase; KEGG- ehi-55.t00018 thymidylate kinase, putative (193 aa)    
Predicted Functional Partners:
Nmar_1627
Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (884 aa)
   
 
  0.947
Nmar_0698
Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant (545 aa)
   
 
  0.942
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family (133 aa)
   
 
  0.936
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP (227 aa)
         
  0.932
Nmar_0947
PFAM- CMP/dCMP deaminase zinc-binding; KEGG- cme-CMQ291C dCMP deaminase (200 aa)
     
 
  0.925
Nmar_1706
PFAM- metal-dependent phosphohydrolase HD sub domain; SMART- metal-dependent phosphohydrolase HD region; KEGG- aae-aq_1910 hypothetical protein (411 aa)
   
   
  0.860
Nmar_0921
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP (332 aa)
         
  0.718
Nmar_1245
PFAM- SMC domain protein; KEGG- sto-ST2108 hypothetical purine NTPase (693 aa)
         
  0.664
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (476 aa)
   
   
  0.647
Nmar_0270
PFAM- AAA ATPase central domain protein; SMART- AAA ATPase; KEGG- mth-MTH240 replication factor C, large subunit (385 aa)
   
   
  0.616
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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