node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Nmar_0240 | Nmar_0270 | Nmar_0240 | Nmar_0270 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | 0.492 |
Nmar_0240 | Nmar_0948 | Nmar_0240 | Nmar_0948 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: tpe:Tpen_0298 DNA polymerase B region. | 0.697 |
Nmar_0240 | dbh | Nmar_0240 | Nmar_0642 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.466 |
Nmar_0240 | fen | Nmar_0240 | Nmar_0703 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.749 |
Nmar_0240 | lig | Nmar_0240 | Nmar_1037 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.698 |
Nmar_0240 | pcn | Nmar_0240 | Nmar_1755 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.992 |
Nmar_0240 | polB | Nmar_0240 | Nmar_0002 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.601 |
Nmar_0240 | priL | Nmar_0240 | Nmar_0065 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.671 |
Nmar_0240 | priS | Nmar_0240 | Nmar_0066 | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.801 |
Nmar_0270 | Nmar_0240 | Nmar_0270 | Nmar_0240 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | 0.492 |
Nmar_0270 | Nmar_0948 | Nmar_0270 | Nmar_0948 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: tpe:Tpen_0298 DNA polymerase B region. | 0.704 |
Nmar_0270 | dbh | Nmar_0270 | Nmar_0642 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.466 |
Nmar_0270 | fen | Nmar_0270 | Nmar_0703 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.838 |
Nmar_0270 | lig | Nmar_0270 | Nmar_1037 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.792 |
Nmar_0270 | pcn | Nmar_0270 | Nmar_1755 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.949 |
Nmar_0270 | polB | Nmar_0270 | Nmar_0002 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.653 |
Nmar_0270 | priL | Nmar_0270 | Nmar_0065 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.767 |
Nmar_0270 | priS | Nmar_0270 | Nmar_0066 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.768 |
Nmar_0948 | Nmar_0240 | Nmar_0948 | Nmar_0240 | PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: tpe:Tpen_0298 DNA polymerase B region. | Replication factor C; PFAM: AAA ATPase central domain protein; Replication factor C; SMART: AAA ATPase; KEGG: smr:Smar_1225 replication factor C. | 0.697 |
Nmar_0948 | Nmar_0270 | Nmar_0948 | Nmar_0270 | PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: tpe:Tpen_0298 DNA polymerase B region. | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: mth:MTH240 replication factor C, large subunit. | 0.704 |