STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1023 aa)    
Predicted Functional Partners:
Kpol_1053p38
DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.999
Kpol_1048p17
DNA_MISMATCH_REPAIR_2 domain-containing protein.
  
0.964
Kpol_1075p4
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 
 
0.954
Kpol_1043p22
DNA_mis_repair domain-containing protein.
 
 0.943
Kpol_1025p8
DNA_mis_repair domain-containing protein.
 
 0.915
Kpol_1020p35
Uncharacterized protein.
 
 0.914
Kpol_1013p12
MutL_C domain-containing protein.
 
 0.910
Kpol_264p9
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.894
Kpol_1023p24
PX domain-containing protein.
    
   0.798
Kpol_1037p15
PX domain-containing protein.
    
   0.798
Your Current Organism:
Vanderwaltozyma polyspora
NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294
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