node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mpop_0779 | Mpop_1638 | Mpop_0779 | Mpop_1638 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.953 |
Mpop_0779 | Mpop_1750 | Mpop_0779 | Mpop_1750 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | 0.927 |
Mpop_0779 | Mpop_2781 | Mpop_0779 | Mpop_2781 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.916 |
Mpop_0779 | fhs | Mpop_0779 | Mpop_0484 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.937 |
Mpop_0779 | glyA | Mpop_0779 | Mpop_3366 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
Mpop_0779 | purH | Mpop_0779 | Mpop_2498 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.935 |
Mpop_0779 | purN | Mpop_0779 | Mpop_2023 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |
Mpop_1638 | Mpop_0779 | Mpop_1638 | Mpop_0779 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | 0.953 |
Mpop_1638 | Mpop_1750 | Mpop_1638 | Mpop_1750 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | 0.527 |
Mpop_1638 | Mpop_2781 | Mpop_1638 | Mpop_2781 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.923 |
Mpop_1638 | fhs | Mpop_1638 | Mpop_0484 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
Mpop_1638 | glyA | Mpop_1638 | Mpop_3366 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
Mpop_1638 | purH | Mpop_1638 | Mpop_2498 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.917 |
Mpop_1638 | purN | Mpop_1638 | Mpop_2023 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.922 |
Mpop_1750 | Mpop_0779 | Mpop_1750 | Mpop_0779 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: mex:Mext_0855 glycine cleavage system T protein. | 0.927 |
Mpop_1750 | Mpop_1638 | Mpop_1750 | Mpop_1638 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.527 |
Mpop_1750 | fhs | Mpop_1750 | Mpop_0484 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
Mpop_1750 | glyA | Mpop_1750 | Mpop_3366 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.419 |
Mpop_1750 | purH | Mpop_1750 | Mpop_2498 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.909 |
Mpop_1750 | purN | Mpop_1750 | Mpop_2023 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: mex:Mext_1798 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |