node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mpop_1074 | Mpop_1081 | Mpop_1074 | Mpop_1081 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | 0.453 |
Mpop_1074 | rutA | Mpop_1074 | Mpop_1075 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | Luciferase-like monooxygenase; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.636 |
Mpop_1074 | rutB | Mpop_1074 | Mpop_1076 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | Isochorismatase hydrolase; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.563 |
Mpop_1074 | rutC | Mpop_1074 | Mpop_1077 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | Endoribonuclease L-PSP; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.543 |
Mpop_1074 | rutD | Mpop_1074 | Mpop_1078 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | Alpha/beta hydrolase fold; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.570 |
Mpop_1074 | rutF | Mpop_1074 | Mpop_1079 | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | Flavin reductase domain protein FMN-binding; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.531 |
Mpop_1080 | Mpop_1081 | Mpop_1080 | Mpop_1081 | KEGG: amr:AM1_0255 hypothetical protein. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | 0.473 |
Mpop_1080 | rutA | Mpop_1080 | Mpop_1075 | KEGG: amr:AM1_0255 hypothetical protein. | Luciferase-like monooxygenase; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.649 |
Mpop_1080 | rutB | Mpop_1080 | Mpop_1076 | KEGG: amr:AM1_0255 hypothetical protein. | Isochorismatase hydrolase; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.697 |
Mpop_1080 | rutC | Mpop_1080 | Mpop_1077 | KEGG: amr:AM1_0255 hypothetical protein. | Endoribonuclease L-PSP; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.671 |
Mpop_1080 | rutD | Mpop_1080 | Mpop_1078 | KEGG: amr:AM1_0255 hypothetical protein. | Alpha/beta hydrolase fold; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.711 |
Mpop_1080 | rutF | Mpop_1080 | Mpop_1079 | KEGG: amr:AM1_0255 hypothetical protein. | Flavin reductase domain protein FMN-binding; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.773 |
Mpop_1081 | Mpop_1074 | Mpop_1081 | Mpop_1074 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: mex:Mext_1739 tetracycline transcriptional regulator YcdC domain protein. | 0.453 |
Mpop_1081 | Mpop_1080 | Mpop_1081 | Mpop_1080 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | KEGG: amr:AM1_0255 hypothetical protein. | 0.473 |
Mpop_1081 | rutA | Mpop_1081 | Mpop_1075 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | Luciferase-like monooxygenase; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.476 |
Mpop_1081 | rutB | Mpop_1081 | Mpop_1076 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | Isochorismatase hydrolase; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.407 |
Mpop_1081 | rutC | Mpop_1081 | Mpop_1077 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | Endoribonuclease L-PSP; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.419 |
Mpop_1081 | rutD | Mpop_1081 | Mpop_1078 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | Alpha/beta hydrolase fold; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.419 |
Mpop_1081 | rutF | Mpop_1081 | Mpop_1079 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_1733 ABC transporter related. | Flavin reductase domain protein FMN-binding; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.489 |
Mpop_4344 | nnrD | Mpop_4344 | Mpop_2329 | PFAM: isochorismatase hydrolase; KEGG: scl:sce3379 putative isochorismatase hydrolase. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.453 |