STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfk26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.975
pfk1
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
 
  
 
0.943
ACL_1395
Ketose bisphosphate aldolase, class-II.
  
 
 0.930
ACL_0413
Carbohydrate and purine kinases (pfkB) family protein; Belongs to the carbohydrate kinase PfkB family.
 
 
 0.923
tktA
Transketolase requires thiamine pyrophosphate as a cofactor; Belongs to the transketolase family.
  
 
 0.920
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.844
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.740
tpiA
Triosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
  
 0.719
rny
Conserved hypothetical surface-anchored protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family.
  
 
 0.684
glgP
Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 
 0.677
Your Current Organism:
Acholeplasma laidlawii
NCBI taxonomy Id: 441768
Other names: A. laidlawii PG-8A, Acholeplasma laidlawii PG-8A, Acholeplasma laidlawii str. PG-8A, Acholeplasma laidlawii strain PG-8A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.