STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GM18_0111KEGG: gem:GM21_0109 DNA ligase D; TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, ligase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; DNA primase small subunit. (892 aa)    
Predicted Functional Partners:
GM18_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.985
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.979
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.976
GM18_0293
KEGG: gbm:Gbem_0265 PHP domain protein; PFAM: PHP domain protein; SMART: DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; phosphoesterase PHP domain protein.
  
 0.960
GM18_2365
KEGG: gbm:Gbem_2506 D,D-heptose 1,7-bisphosphate phosphatase; TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Haloacid dehalogenase domain protein hydrolase.
   
 0.850
GM18_1928
PFAM: SMC domain protein; KEGG: gem:GM21_1922 SMC domain protein.
   
 0.804
GM18_1927
PFAM: metallophosphoesterase; KEGG: gbm:Gbem_2302 metallophosphoesterase.
  
 0.768
GM18_4203
SMART: helicase c2; DEAD-like helicase; KEGG: gbm:Gbem_3770 helicase C2.
  
 
 0.736
GM18_3876
DNA-directed DNA polymerase; KEGG: gbm:Gbem_0500 UMUC domain protein DNA-repair protein; PFAM: UMUC domain protein DNA-repair protein.
 
 
 0.733
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
     
 0.698
Your Current Organism:
Geobacter sp. M18
NCBI taxonomy Id: 443143
Other names: G. sp. M18
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