node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GM21_0190 | GM21_0300 | GM21_0190 | GM21_0300 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | KEGG: par:Psyc_1719 heat shock protein 90. | 0.945 |
GM21_0190 | GM21_1622 | GM21_0190 | GM21_1622 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | KEGG: gbm:Gbem_2603 molecular chaperone-like protein. | 0.970 |
GM21_0190 | clpB | GM21_0190 | GM21_0583 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.921 |
GM21_0190 | clpP | GM21_0190 | GM21_3011 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.669 |
GM21_0190 | dnaK | GM21_0190 | GM21_3574 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.970 |
GM21_0190 | groL | GM21_0190 | GM21_0233 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.870 |
GM21_0190 | groS | GM21_0190 | GM21_0232 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.788 |
GM21_0190 | grpE | GM21_0190 | GM21_3575 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.901 |
GM21_0190 | htpG | GM21_0190 | GM21_1803 | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.945 |
GM21_0300 | GM21_0190 | GM21_0300 | GM21_0190 | KEGG: par:Psyc_1719 heat shock protein 90. | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | 0.945 |
GM21_0300 | GM21_1622 | GM21_0300 | GM21_1622 | KEGG: par:Psyc_1719 heat shock protein 90. | KEGG: gbm:Gbem_2603 molecular chaperone-like protein. | 0.976 |
GM21_0300 | clpB | GM21_0300 | GM21_0583 | KEGG: par:Psyc_1719 heat shock protein 90. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.833 |
GM21_0300 | clpP | GM21_0300 | GM21_3011 | KEGG: par:Psyc_1719 heat shock protein 90. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.404 |
GM21_0300 | dnaJ | GM21_0300 | GM21_3573 | KEGG: par:Psyc_1719 heat shock protein 90. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.865 |
GM21_0300 | dnaK | GM21_0300 | GM21_3574 | KEGG: par:Psyc_1719 heat shock protein 90. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.976 |
GM21_0300 | groL | GM21_0300 | GM21_0233 | KEGG: par:Psyc_1719 heat shock protein 90. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.909 |
GM21_0300 | groS | GM21_0300 | GM21_0232 | KEGG: par:Psyc_1719 heat shock protein 90. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.845 |
GM21_0300 | grpE | GM21_0300 | GM21_3575 | KEGG: par:Psyc_1719 heat shock protein 90. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.843 |
GM21_1622 | GM21_0190 | GM21_1622 | GM21_0190 | KEGG: gbm:Gbem_2603 molecular chaperone-like protein. | PFAM: pentapeptide repeat protein; KEGG: gbm:Gbem_0207 pentapeptide repeat protein. | 0.970 |
GM21_1622 | GM21_0300 | GM21_1622 | GM21_0300 | KEGG: gbm:Gbem_2603 molecular chaperone-like protein. | KEGG: par:Psyc_1719 heat shock protein 90. | 0.976 |