node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GM21_0048 | GM21_0389 | GM21_0048 | GM21_0389 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | 0.566 |
GM21_0048 | GM21_0392 | GM21_0048 | GM21_0392 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | 0.919 |
GM21_0048 | GM21_2289 | GM21_0048 | GM21_2289 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.912 |
GM21_0048 | GM21_3480 | GM21_0048 | GM21_3480 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class V; KEGG: gbm:Gbem_3418 aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.912 |
GM21_0048 | gcvPA | GM21_0048 | GM21_0391 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.917 |
GM21_0048 | glyA | GM21_0048 | GM21_1160 | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
GM21_0389 | GM21_0048 | GM21_0389 | GM21_0048 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.566 |
GM21_0389 | GM21_0392 | GM21_0389 | GM21_0392 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | 0.999 |
GM21_0389 | GM21_0718 | GM21_0389 | GM21_0718 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein; KEGG: gme:Gmet_2764 dihydrolipoamide dehydrogenase. | 0.973 |
GM21_0389 | GM21_3566 | GM21_0389 | GM21_3566 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: gme:Gmet_1896 dihydrolipoamide dehydrogenase. | 0.977 |
GM21_0389 | gcvH | GM21_0389 | GM21_0390 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
GM21_0389 | gcvH-2 | GM21_0389 | GM21_2653 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
GM21_0389 | gcvPA | GM21_0389 | GM21_0391 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
GM21_0389 | glyA | GM21_0389 | GM21_1160 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
GM21_0392 | GM21_0048 | GM21_0392 | GM21_0048 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; TIGRFAM: pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.919 |
GM21_0392 | GM21_0389 | GM21_0392 | GM21_0389 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: gbm:Gbem_0395 glycine cleavage system T protein. | 0.999 |
GM21_0392 | GM21_0718 | GM21_0392 | GM21_0718 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein; KEGG: gme:Gmet_2764 dihydrolipoamide dehydrogenase. | 0.944 |
GM21_0392 | GM21_2289 | GM21_0392 | GM21_2289 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.921 |
GM21_0392 | GM21_3480 | GM21_0392 | GM21_3480 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class V; KEGG: gbm:Gbem_3418 aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.921 |
GM21_0392 | GM21_3566 | GM21_0392 | GM21_3566 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: gbm:Gbem_0398 glycine dehydrogenase (decarboxylating). | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: gme:Gmet_1896 dihydrolipoamide dehydrogenase. | 0.950 |