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FEN1 protein (Nelumbo nucifera) - STRING interaction network
"FEN1" - Flap endonuclease 1 in Nelumbo nucifera
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FEN1Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (418 aa)    
Predicted Functional Partners:
XP_010262728.1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (264 aa)
     
 
  0.989
XP_010256721.1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (266 aa)
     
 
  0.989
XP_010248167.1
DNA ligase 6-like; Protein artemis-like (871 aa)
   
 
  0.986
XP_010270328.1
DNA polymerase delta catalytic subunit (1084 aa)
     
 
  0.969
XP_010249361.1
DNA replication licensing factor MCM2; Belongs to the MCM family (941 aa)
   
 
  0.967
XP_010257868.1
WD repeat and HMG-box DNA-binding protein 1 (971 aa)
     
 
  0.963
XP_010263328.1
DNA polymerase delta small subunit isoform X1 (440 aa)
     
 
  0.957
XP_010274069.1
Putative bifunctional dihydrofolate reductase-thymidylate synthase isoform X1 (458 aa)
   
   
  0.957
XP_010254749.1
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (578 aa)
   
   
  0.957
XP_010270152.1
DNA polymerase; Derived by automated computational analysis using gene prediction method- Gnomon. Supporting evidence includes similarity to- 1 Protein, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 5 samples with support for all annotated introns (1542 aa)
     
 
  0.956
Your Current Organism:
Nelumbo nucifera
NCBI taxonomy Id: 4432
Other names: Indian lotus, N. nucifera, Nelumbo nucifera, Nelumbo nucifera Gaertn., padma, sacred lotus
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