STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tneu_0067TIGRFAM: adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: pis:Pisl_1114 putative adenylyl cyclase CyaB. (176 aa)    
Predicted Functional Partners:
Tneu_0651
PFAM: nucleoside diphosphate kinase; KEGG: pis:Pisl_1626 nucleoside-diphosphate kinase.
    
  0.901
Tneu_0378
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: pis:Pisl_0226 anaerobic ribonucleoside triphosphate reductase.
     
  0.900
Tneu_1020
PFAM: NUDIX hydrolase; KEGG: pis:Pisl_0088 NUDIX hydrolase.
    
  0.900
Tneu_1537
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
Tneu_1993
PFAM: NUDIX hydrolase; KEGG: pis:Pisl_0673 NUDIX hydrolase.
    
  0.900
gch3
GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
  
  
  0.831
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
    
  0.811
folE
PFAM: GTP cyclohydrolase I; KEGG: pis:Pisl_1636 GTP cyclohydrolase I.
     
  0.800
Tneu_0066
KEGG: pis:Pisl_1113 hypothetical protein.
       0.799
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
       0.783
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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