STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top6ADNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (367 aa)    
Predicted Functional Partners:
top6B
DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
 
 
 0.999
Tneu_1633
Rad51 domain protein; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
    
 
 0.748
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
    
 
 0.748
Tneu_0726
PFAM: ERCC4 domain protein; KEGG: pis:Pisl_1707 ERCC4 domain protein.
    
 
 0.658
Tneu_1393
Phosphate uptake regulator, PhoU; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; PhoU family protein; KEGG: pis:Pisl_0860 phosphate uptake regulator, PhoU.
       0.650
Tneu_0861
PFAM: deoxyhypusine synthase; KEGG: pis:Pisl_0783 putative deoxyhypusine synthase.
 
   
 0.604
Tneu_1444
PFAM: SMC domain protein; KEGG: pis:Pisl_0884 SMC domain protein.
  
 
 0.584
Tneu_0499
KEGG: pcl:Pcal_0470 SMC domain protein.
    
 0.527
Tneu_1819
PFAM: SMC domain protein; KEGG: pis:Pisl_0302 SMC domain protein.
    
 0.527
Tneu_1820
PFAM: metallophosphoesterase; KEGG: pis:Pisl_0301 metallophosphoesterase.
   
 0.526
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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