STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gch3GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (221 aa)    
Predicted Functional Partners:
Tneu_1742
KEGG: pcl:Pcal_1122 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein.
 
     0.861
Tneu_1741
PFAM: 34-dihydroxy-2-butanone 4-phosphate synthase; KEGG: pis:Pisl_0386 3,4-dihydroxy-2-butanone 4-phosphate synthase.
 
     0.840
Tneu_0067
TIGRFAM: adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: pis:Pisl_1114 putative adenylyl cyclase CyaB.
  
  
  0.831
Tneu_0378
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: pis:Pisl_0226 anaerobic ribonucleoside triphosphate reductase.
     
  0.800
Tneu_0651
PFAM: nucleoside diphosphate kinase; KEGG: pis:Pisl_1626 nucleoside-diphosphate kinase.
     
  0.800
Tneu_1020
PFAM: NUDIX hydrolase; KEGG: pis:Pisl_0088 NUDIX hydrolase.
     
  0.800
Tneu_1993
PFAM: NUDIX hydrolase; KEGG: pis:Pisl_0673 NUDIX hydrolase.
     
  0.800
Tneu_1744
PFAM: Creatininase; KEGG: pis:Pisl_0383 creatininase.
 
   
 0.730
hjc
Resolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
  
     0.717
Tneu_1931
PFAM: Protein of unknown function DUF371; KEGG: pcl:Pcal_2061 protein of unknown function DUF371.
  
     0.603
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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