node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tneu_0296 | Tneu_0957 | Tneu_0296 | Tneu_0957 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.879 |
Tneu_0296 | Tneu_1898 | Tneu_0296 | Tneu_1898 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | 0.890 |
Tneu_0296 | Tneu_1899 | Tneu_0296 | Tneu_1899 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pis:Pisl_0115 uroporphyrin-III C-methyltransferase. | 0.934 |
Tneu_0296 | cbiT | Tneu_0296 | Tneu_0299 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.999 |
Tneu_0296 | cobS | Tneu_0296 | Tneu_0289 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.934 |
Tneu_0296 | hemA | Tneu_0296 | Tneu_1917 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.888 |
Tneu_0296 | hemC | Tneu_0296 | Tneu_0968 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.884 |
Tneu_0296 | hemL | Tneu_0296 | Tneu_1900 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pis:Pisl_0114 glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.877 |
Tneu_0957 | Tneu_0296 | Tneu_0957 | Tneu_0296 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | 0.879 |
Tneu_0957 | Tneu_1898 | Tneu_0957 | Tneu_1898 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | 0.933 |
Tneu_0957 | Tneu_1899 | Tneu_0957 | Tneu_1899 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pis:Pisl_0115 uroporphyrin-III C-methyltransferase. | 0.695 |
Tneu_0957 | cbiT | Tneu_0957 | Tneu_0299 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.435 |
Tneu_0957 | cobS | Tneu_0957 | Tneu_0289 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.435 |
Tneu_0957 | hemA | Tneu_0957 | Tneu_1917 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.830 |
Tneu_0957 | hemC | Tneu_0957 | Tneu_0968 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.998 |
Tneu_0957 | hemL | Tneu_0957 | Tneu_1900 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pis:Pisl_0114 glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.992 |
Tneu_1898 | Tneu_0296 | Tneu_1898 | Tneu_0296 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: pai:PAE0343 precorrin-8X methylmutase. | 0.890 |
Tneu_1898 | Tneu_0957 | Tneu_1898 | Tneu_0957 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pis:Pisl_0042 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.933 |
Tneu_1898 | Tneu_1899 | Tneu_1898 | Tneu_1899 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pis:Pisl_0115 uroporphyrin-III C-methyltransferase. | 0.987 |
Tneu_1898 | cbiT | Tneu_1898 | Tneu_0299 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pis:Pisl_0116 uroporphyrinogen III synthase HEM4. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.464 |