node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABX01326.1 | ABX01784.1 | MmarC6_0509 | MmarC6_0969 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | 0.893 |
ABX01326.1 | ABX02454.1 | MmarC6_0509 | MmarC6_1642 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | KEGG: mvn:Mevan_0346 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.513 |
ABX01326.1 | ABX02547.1 | MmarC6_0509 | MmarC6_1735 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.990 |
ABX01326.1 | ilvC | MmarC6_0509 | MmarC6_0233 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.765 |
ABX01326.1 | ilvE | MmarC6_0509 | MmarC6_0820 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.421 |
ABX01326.1 | thrB | MmarC6_0509 | MmarC6_0658 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.850 |
ABX01634.1 | ABX01784.1 | MmarC6_0817 | MmarC6_0969 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | 0.984 |
ABX01634.1 | ABX02454.1 | MmarC6_0817 | MmarC6_1642 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | KEGG: mvn:Mevan_0346 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.974 |
ABX01634.1 | asd | MmarC6_0817 | MmarC6_1282 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.861 |
ABX01634.1 | ilvC | MmarC6_0817 | MmarC6_0233 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.927 |
ABX01634.1 | ilvD | MmarC6_0817 | MmarC6_0633 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | KEGG: mvn:Mevan_1329 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.692 |
ABX01634.1 | ilvE | MmarC6_0817 | MmarC6_0820 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.792 |
ABX01634.1 | thrB | MmarC6_0817 | MmarC6_0658 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.997 |
ABX01784.1 | ABX01326.1 | MmarC6_0969 | MmarC6_0509 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | PFAM: Methionine synthase vitamin-B12 independent; KEGG: mvn:Mevan_1388 methionine synthase vitamin-B12 independent. | 0.893 |
ABX01784.1 | ABX01634.1 | MmarC6_0969 | MmarC6_0817 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.984 |
ABX01784.1 | ABX02454.1 | MmarC6_0969 | MmarC6_1642 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | KEGG: mvn:Mevan_0346 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.996 |
ABX01784.1 | ABX02547.1 | MmarC6_0969 | MmarC6_1735 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.849 |
ABX01784.1 | asd | MmarC6_0969 | MmarC6_1282 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.995 |
ABX01784.1 | ilvC | MmarC6_0969 | MmarC6_0233 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.654 |
ABX01784.1 | ilvD | MmarC6_0969 | MmarC6_0633 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mvn:Mevan_1004 homoserine dehydrogenase. | KEGG: mvn:Mevan_1329 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.701 |