node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABX01312.1 | ABX02133.1 | MmarC6_0494 | MmarC6_1320 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein ki [...] | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | 0.403 |
ABX01312.1 | thi4 | MmarC6_0494 | MmarC6_1321 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein ki [...] | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.629 |
ABX01706.1 | ABX01747.1 | MmarC6_0891 | MmarC6_0932 | KEGG: mvn:Mevan_1074 hypothetical protein. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_1204 radical SAM domain protein. | 0.629 |
ABX01706.1 | thi4 | MmarC6_0891 | MmarC6_1321 | KEGG: mvn:Mevan_1074 hypothetical protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.597 |
ABX01747.1 | ABX01706.1 | MmarC6_0932 | MmarC6_0891 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_1204 radical SAM domain protein. | KEGG: mvn:Mevan_1074 hypothetical protein. | 0.629 |
ABX01747.1 | thi4 | MmarC6_0932 | MmarC6_1321 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_1204 radical SAM domain protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.644 |
ABX01747.1 | thiC | MmarC6_0932 | MmarC6_0765 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_1204 radical SAM domain protein. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.443 |
ABX01847.1 | thi4 | MmarC6_1032 | MmarC6_1321 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mvn:Mevan_0944 phosphomethylpyrimidine kinase. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.898 |
ABX01847.1 | thiC | MmarC6_1032 | MmarC6_0765 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mvn:Mevan_0944 phosphomethylpyrimidine kinase. | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.997 |
ABX01847.1 | thiI | MmarC6_1032 | MmarC6_1319 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mvn:Mevan_0944 phosphomethylpyrimidine kinase. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.551 |
ABX02133.1 | ABX01312.1 | MmarC6_1320 | MmarC6_0494 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein ki [...] | 0.403 |
ABX02133.1 | ABX02135.1 | MmarC6_1320 | MmarC6_1322 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: mvn:Mevan_0662 ribosomal-protein-alanine acetyltransferase. | 0.467 |
ABX02133.1 | ABX02136.1 | MmarC6_1320 | MmarC6_1323 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_0661 radical SAM domain protein. | 0.537 |
ABX02133.1 | ABX02138.1 | MmarC6_1320 | MmarC6_1325 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | KEGG: mvn:Mevan_0659 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein; TOPRIM domain protein; SMART: Toprim sub domain protein; Belongs to the UPF0292 family. | 0.504 |
ABX02133.1 | thi4 | MmarC6_1320 | MmarC6_1321 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.584 |
ABX02133.1 | thiI | MmarC6_1320 | MmarC6_1319 | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.700 |
ABX02135.1 | ABX02133.1 | MmarC6_1322 | MmarC6_1320 | TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: mvn:Mevan_0662 ribosomal-protein-alanine acetyltransferase. | PFAM: PP-loop domain protein; KEGG: mvn:Mevan_0175 PP-loop domain protein. | 0.467 |
ABX02135.1 | ABX02136.1 | MmarC6_1322 | MmarC6_1323 | TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: mvn:Mevan_0662 ribosomal-protein-alanine acetyltransferase. | PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mvn:Mevan_0661 radical SAM domain protein. | 0.931 |
ABX02135.1 | ABX02138.1 | MmarC6_1322 | MmarC6_1325 | TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: mvn:Mevan_0662 ribosomal-protein-alanine acetyltransferase. | KEGG: mvn:Mevan_0659 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein; TOPRIM domain protein; SMART: Toprim sub domain protein; Belongs to the UPF0292 family. | 0.693 |
ABX02135.1 | thi4 | MmarC6_1322 | MmarC6_1321 | TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: mvn:Mevan_0662 ribosomal-protein-alanine acetyltransferase. | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.693 |