node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABX01072.1 | ABX01347.1 | MmarC6_0251 | MmarC6_0530 | KEGG: mvn:Mevan_1559 hypothetical protein. | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | 0.912 |
ABX01072.1 | ABX01647.1 | MmarC6_0251 | MmarC6_0830 | KEGG: mvn:Mevan_1559 hypothetical protein. | KEGG: mvn:Mevan_1127 hypothetical protein. | 0.928 |
ABX01072.1 | ABX02439.1 | MmarC6_0251 | MmarC6_1627 | KEGG: mvn:Mevan_1559 hypothetical protein. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mvn:Mevan_0355 nucleic acid binding OB-fold tRNA/helicase-type. | 0.940 |
ABX01072.1 | fen | MmarC6_0251 | MmarC6_1360 | KEGG: mvn:Mevan_1559 hypothetical protein. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.961 |
ABX01072.1 | mre11 | MmarC6_0251 | MmarC6_1333 | KEGG: mvn:Mevan_1559 hypothetical protein. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.742 |
ABX01072.1 | pcn | MmarC6_0251 | MmarC6_0960 | KEGG: mvn:Mevan_1559 hypothetical protein. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.929 |
ABX01072.1 | rad50 | MmarC6_0251 | MmarC6_1332 | KEGG: mvn:Mevan_1559 hypothetical protein. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.710 |
ABX01072.1 | radA | MmarC6_0251 | MmarC6_1450 | KEGG: mvn:Mevan_1559 hypothetical protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.902 |
ABX01072.1 | topA | MmarC6_0251 | MmarC6_1699 | KEGG: mvn:Mevan_1559 hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.972 |
ABX01347.1 | ABX01072.1 | MmarC6_0530 | MmarC6_0251 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | KEGG: mvn:Mevan_1559 hypothetical protein. | 0.912 |
ABX01347.1 | ABX01647.1 | MmarC6_0530 | MmarC6_0830 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | KEGG: mvn:Mevan_1127 hypothetical protein. | 0.970 |
ABX01347.1 | ABX02439.1 | MmarC6_0530 | MmarC6_1627 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mvn:Mevan_0355 nucleic acid binding OB-fold tRNA/helicase-type. | 0.926 |
ABX01347.1 | fen | MmarC6_0530 | MmarC6_1360 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | XPG I domain protein; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] | 0.986 |
ABX01347.1 | hjc | MmarC6_0530 | MmarC6_0616 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | Resolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.425 |
ABX01347.1 | mre11 | MmarC6_0530 | MmarC6_1333 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.751 |
ABX01347.1 | pcn | MmarC6_0530 | MmarC6_0960 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.997 |
ABX01347.1 | rad50 | MmarC6_0530 | MmarC6_1332 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.931 |
ABX01347.1 | radA | MmarC6_0530 | MmarC6_1450 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.913 |
ABX01347.1 | topA | MmarC6_0530 | MmarC6_1699 | KEGG: mvn:Mevan_1367 DNA polymerase Pol2; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.870 |
ABX01647.1 | ABX01072.1 | MmarC6_0830 | MmarC6_0251 | KEGG: mvn:Mevan_1127 hypothetical protein. | KEGG: mvn:Mevan_1559 hypothetical protein. | 0.928 |