STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpPEndopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (195 aa)    
Predicted Functional Partners:
Emin_1526
ATPases with chaperone activity, ATP-binding subunit; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: sth:STH3133 class III stress response-related ATPase; Belongs to the ClpA/ClpB family.
 
 
 0.875
Emin_1101
Polyketide synthase; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: rrs:RoseRS_2905 beta-ketoacyl synthase.
  
 
 0.701
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.640
Emin_0765
PilE-like protein; KEGG: hch:HCH_06933 Tfp pilus assembly protein, major pilin PilA.
       0.610
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
 
 0.586
def
N-Formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
 
  
 0.576
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.572
Emin_1128
Ech hydrogenase subunit F; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: ppd:Ppro_0597 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
   
 
 0.512
Emin_0995
Non-ribosomal peptide synthetase; TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; Thioesterase; condensation domain protein; phosphopantetheine-binding; KEGG: bld:BLi00401 lichenysin synthetase A.
   
 
 0.511
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.510
Your Current Organism:
Elusimicrobium minutum
NCBI taxonomy Id: 445932
Other names: E. minutum Pei191, Elusimicrobium minutum Pei191, Elusimicrobium minutum str. Pei191, Elusimicrobium minutum strain Pei191
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.