STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhsPutative formyltetrahydrofolate synthetase; PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: cth:Cthe_2399 formate--tetrahydrofolate ligase. (556 aa)    
Predicted Functional Partners:
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.994
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: sat:SYN_02440 phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.979
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.963
purN
Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.961
Emin_1354
TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: fno:Fnod_0976 glycine cleavage system T protein.
  
 0.947
Emin_1240
Methenyl tetrahydrofolate cyclohydrolase-like protein; KEGG: drm:Dred_1074 formiminotransferase-cyclodeaminase.
    
 0.933
Emin_0528
KEGG: tte:TTE0450 glutamate formiminotransferase; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein.
    
  0.908
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.901
Emin_1053
Hypothetical protein; KEGG: aoe:Clos_1144 anaerobic ribonucleoside-triphosphate reductase.
  
    0.780
rsmH
Putative S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
 
      0.744
Your Current Organism:
Elusimicrobium minutum
NCBI taxonomy Id: 445932
Other names: E. minutum Pei191, Elusimicrobium minutum Pei191, Elusimicrobium minutum str. Pei191, Elusimicrobium minutum strain Pei191
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