STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amir_2105TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; KEGG: sus:Acid_0680 methylmalonate-semialdehyde dehydrogenase [acylating]. (513 aa)    
Predicted Functional Partners:
Amir_2104
PFAM: aminotransferase class-III; KEGG: sus:Acid_7662 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.985
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.923
Amir_2275
PFAM: AMP-dependent synthetase and ligase; KEGG: eba:ebA1206 putative acetyl-coenzyme A synthetase.
   
 0.923
Amir_3076
Acetylornithine transaminase; PFAM: aminotransferase class-III; KEGG: aba:Acid345_3989 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.920
Amir_4372
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: mxa:MXAN_6987 fatty oxidation complex, alpha subunit.
  
 0.914
Amir_5669
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: pmy:Pmen_2590 short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase.
  
 0.914
Amir_2418
KEGG: rru:Rru_A3000 formate acetyltransferase; TIGRFAM: formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical.
  
 
 0.910
Amir_0699
acetyl-CoA acetyltransferase; KEGG: aba:Acid345_2470 3-ketoacyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 0.904
Amir_6972
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: pmy:Pmen_0745 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 0.904
Amir_1544
KEGG: sfu:Sfum_1403 acetyl-CoA acetyltransferases; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
   
  0.903
Your Current Organism:
Actinosynnema mirum
NCBI taxonomy Id: 446462
Other names: A. mirum DSM 43827, Actinosynnema mirum DSM 43827, Actinosynnema mirum str. DSM 43827, Actinosynnema mirum strain DSM 43827
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