STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cfla_0584KEGG: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (354 aa)    
Predicted Functional Partners:
Cfla_1252
PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: aau:AAur_3867 ATP-dependent DNA ligase.
   
 0.983
Cfla_1903
KEGG: stp:Strop_3968 ATP dependent DNA ligase; TIGRFAM: DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein.
   
 0.978
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.883
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.814
Cfla_1901
PHP domain protein; KEGG: sgr:SGR_483 hypothetical protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein.
 
   
 0.533
Cfla_0585
PFAM: PspC domain protein; KEGG: kra:Krad_0132 phage shock protein C, PspC.
       0.505
Cfla_1504
KEGG: DNA-formamidopyrimidine glycosylase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein.
 
     0.484
Cfla_3074
KEGG: hydrolase of the alpha/beta-hydrolase fold family.
 
     0.450
Cfla_1357
KEGG: putative viral-like DNA topoisomerase.
 
     0.445
Your Current Organism:
Cellulomonas flavigena
NCBI taxonomy Id: 446466
Other names: C. flavigena DSM 20109, Cellulomonas flavigena DSM 20109, Cellulomonas flavigena str. DSM 20109, Cellulomonas flavigena strain DSM 20109
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