node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACZ21536.1 | ACZ22950.1 | Sked_16010 | Sked_30500 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.912 |
ACZ21536.1 | ACZ23603.1 | Sked_16010 | Sked_37200 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase II (cobalamin-independent). | 0.970 |
ACZ21536.1 | fmt | Sked_16010 | Sked_18090 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.932 |
ACZ21536.1 | gltX | Sked_16010 | Sked_11010 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.539 |
ACZ21536.1 | leuS | Sked_16010 | Sked_13250 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | leucyl-tRNA synthetase; PFAM: Anticodon-binding domain; tRNA synthetases class I (M); TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.555 |
ACZ21536.1 | metE | Sked_16010 | Sked_00580 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.970 |
ACZ21536.1 | metG | Sked_16010 | Sked_30340 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.912 |
ACZ22950.1 | ACZ21536.1 | Sked_30500 | Sked_16010 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.912 |
ACZ22950.1 | ACZ23603.1 | Sked_30500 | Sked_37200 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine synthase II (cobalamin-independent). | 0.900 |
ACZ22950.1 | argS | Sked_30500 | Sked_09800 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | PFAM: tRNA synthetases class I (R); DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; TIGRFAM: arginyl-tRNA synthetase. | 0.861 |
ACZ22950.1 | fmt | Sked_30500 | Sked_18090 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
ACZ22950.1 | gltX | Sked_30500 | Sked_11010 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.913 |
ACZ22950.1 | leuS | Sked_30500 | Sked_13250 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | leucyl-tRNA synthetase; PFAM: Anticodon-binding domain; tRNA synthetases class I (M); TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.921 |
ACZ22950.1 | metE | Sked_30500 | Sked_00580 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
ACZ22950.1 | metG | Sked_30500 | Sked_30340 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.918 |
ACZ22950.1 | pheT | Sked_30500 | Sked_22370 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | phenylalanyl-tRNA synthetase beta subunit; PFAM: Putative tRNA binding domain; Ferredoxin-fold anticodon binding domain; B3/4 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.859 |
ACZ22950.1 | proS | Sked_30500 | Sked_23500 | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | prolyl-tRNA synthetase, family II; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and i [...] | 0.819 |
ACZ23603.1 | ACZ21536.1 | Sked_37200 | Sked_16010 | Methionine synthase II (cobalamin-independent). | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.970 |
ACZ23603.1 | ACZ22950.1 | Sked_37200 | Sked_30500 | Methionine synthase II (cobalamin-independent). | PFAM: tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.900 |
ACZ23603.1 | metE | Sked_37200 | Sked_00580 | Methionine synthase II (cobalamin-independent). | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |