STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACZ23471.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme. (551 aa)    
Predicted Functional Partners:
ACZ21809.1
Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.998
ACZ23472.1
Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Transketolase, pyrimidine binding domain; Transketolase, C-terminal domain.
 0.998
ACZ23473.1
PFAM: Dehydrogenase E1 component; TIGRFAM: pyruvate dehydrogenase E1 component, alpha subunit.
 
 0.998
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.996
ACZ21482.1
Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: dihydrolipoamide dehydrogenase.
 0.991
ACZ21352.1
Pyruvate dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.981
ACZ22503.1
PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family.
  
 0.959
ACZ20904.1
PFAM: Transketolase, pyrimidine binding domain; Dehydrogenase E1 component; 2-oxoacid dehydrogenases acyltransferase (catalytic domain); TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
 
0.958
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.954
ACZ22752.1
Phosphotransacetylase; PFAM: Phosphate acetyl/butaryl transferase; DRTGG domain; TIGRFAM: phosphate acetyltransferase.
  
 
 0.950
Your Current Organism:
Sanguibacter keddieii
NCBI taxonomy Id: 446469
Other names: S. keddieii DSM 10542, Sanguibacter keddieii DSM 10542, Sanguibacter keddieii str. DSM 10542, Sanguibacter keddieii strain DSM 10542
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