STRINGSTRING
fhit protein (Dictyostelium discoideum) - STRING interaction network
"fhit" - Bis(5'-adenosyl)-triphosphatase in Dictyostelium discoideum
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhitBis(5’-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5’-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5’- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival. Plays a role in the induction of apoptosis via p53/TP53, SRC and AKT1 signaling pathways. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5’-adenosyl) triphosphate or related compounds, but [...] (149 aa)    
Predicted Functional Partners:
DDB0186809
annotation not available (395 aa)
         
    0.900
DDB0201560
HIT domain-containing protein DDB_G0272839 (390 aa)
     
   
  0.713
DDB0238044
COBW domain-containing protein DDB_G0274527; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily (475 aa)
 
 
        0.654
pyd3
Beta-ureidopropionase; Converts N-carbamoyl-beta-aminoisobutyrate and N- carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide (391 aa)
   
   
  0.631
mlh1
DNA mismatch repair protein Mlh1; Heterodimerizes with pms1 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (msh2-msh6) or MutS beta (msh2-msh3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of rfc and pcna is sufficient to activate endonuclease activity of pms1. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease exo1 to degrade the strand containing [...] (884 aa)
         
  0.584
snpC
Gamma-soluble NSF attachment protein; May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins; Belongs to the SNAP family (324 aa)
           
  0.576
DDB0187750
Uncharacterized protein (256 aa)
   
   
  0.565
DDB0219436
Uncharacterized protein (134 aa)
           
  0.548
pkiA
Protein pkiA (127 aa)
           
  0.548
fdxr
Probable NADPH-adrenodoxin oxidoreductase, mitochondrial (515 aa)
     
 
  0.471
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: ATCC 11735, D. discoideum, Dictyostelium discoideum, IMI 69094
Server load: low (7%) [HD]