STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0185950Uncharacterized protein. (721 aa)    
Predicted Functional Partners:
DDB0218853
Uncharacterized protein.
   
 0.941
rbbD
Probable histone-binding protein rbbD; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism (By similarity).
   
 0.926
hdaA
Type-1 histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Belongs to the histone deacetylase family. HD type 1 subfamily.
   
 0.924
DDB0216409
Paired amphipathic helix (PAH) containing protein.
   
 
 0.878
hdaB
Histone deacetylase B; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the timing of gene expression during the development and in the definition aspects of the phenotype that mediate social behavior in genetically heterogeneous groups.
   
 
 0.856
DDB_G0277341
PHD zinc finger-containing protein.
   
 0.837
DDB0185724
SAP30_Sin3_bdg domain-containing protein.
   
 
  0.801
DDB0218654
Uncharacterized protein.
     
 0.754
DDB_G0283075
NuA4 complex subunit EAF3 homolog; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Also component of a complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
   
 
 0.727
gflC
PHD zinc finger-containing protein.
   
 
 0.597
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: medium (70%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.