STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
amtCAmmonium transporter 3; Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression (431 aa)    
Predicted Functional Partners:
rhgA
Rhesus-like glycoprotein A; May be a carbon dioxide/bicarbonate transporter
  
   
 0.794
rhgB
Rhesus-like glycoprotein B; May be a carbon dioxide/bicarbonate transporter
   
  
 0.745
dhkC
Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...]
 
  
 
 0.711
argC
Bifunctional protein argC, mitochondrialN-acetyl-gamma-glutamyl-phosphate reductaseAcetylglutamate kinase; In the C-terminal section; belongs to the NAGSA dehydrogenase family
  
  
 0.683
DDB0205543
Uncharacterized protein; Cytochrome b5 reductase
   
  
 0.627
dhkI-2
Histidine kinase
    
 
 0.619
DDB0188301
annotation not available
     
 0.551
DDB0206266
annotation not available
      
 0.544
dokA
Hybrid signal transduction protein dokA; Part of the osmoregulatory pathway which leads to the increase of intracellular cAMP concentration in response to hyperosmotic stress. Thought to negatively regulate the rdeA-regA pathway by acting as a phosphatase towards the HPt protein rdeA. Has probably no histidine kinase activity
 
 
 
 0.532
cshA
Citrate synthase, peroxisomal; Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development
   
  
 0.452
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: ATCC 11735, D. discoideum, Dictyostelium discoideum, IMI 69094
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