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pkbA protein (Dictyostelium discoideum) - STRING interaction network
"pkbA" - RAC family serine/threonine-protein kinase homolog in Dictyostelium discoideum
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily (444 aa)    
Predicted Functional Partners:
pia
Protein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function red [...] (1148 aa)
       
 
  0.877
lst8
Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family (304 aa)
 
   
 
  0.755
pdkA
Probable serine/threonine-protein kinase pdkA; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily (686 aa)
       
 
0.751
rasC
Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family (189 aa)
       
 
  0.750
DDB0206196
InsP6 kinase; Belongs to the inositol phosphokinase (IPK) family (716 aa)
     
 
  0.742
DDB0218526
annotation not available (617 aa)
     
 
  0.742
DDB0204639
annotation not available (284 aa)
     
 
  0.742
DDB0203614
annotation not available (307 aa)
     
 
  0.742
rps6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (236 aa)
 
   
 
  0.718
raptor
Protein raptor homolog (1509 aa)
     
 
  0.716
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: ATCC 11735, D. discoideum, Dictyostelium discoideum, IMI 69094
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