STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
roco11Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily (1487 aa)    
Predicted Functional Partners:
spnA
Integrin-linked kinase-associated serine/threonine phosphatase 2c; Involved in cell-type differentiation and morphogenesis. Dephosphorylates casein; in vitro. May also be involved as modulators or transducers in various transmembrane signaling systems
  
 0.823
DDB0238569
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; LIM-type zinc finger-containing protein
    
 0.680
ndrD
Ndr family protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
   
 
0.638
DDB0231326
Hypothetical protein; Probable serine/threonine-protein kinase DDB_G0277071; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
   
 0.626
gefB
Ras guanine nucleotide exchange factor; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement
   
   0.622
gacHH
Kelch repeat-containing protein; Rho GTPase-activating protein involved in the signal transduction pathway
   
 0.621
pikB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta; Phosphatidylinositol 3-kinase 2
   
   0.609
gbpC
Dep domain-containing protein; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase
  
0.602
gefC
Ras nucleotide exchange factor; Promotes the exchange of Ras-bound GDP by GTP
  
  0.602
DDB0202116
Uncharacterized protein
   
 
0.601
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: ATCC 11735, D. discoideum, IMI 69094
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