STRINGSTRING
DDB0229339 protein (Dictyostelium discoideum) - STRING interaction network
"DDB0229339" - Probable serine/threonine-protein kinase DDB_G0291664 in Dictyostelium discoideum
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0229339Probable serine/threonine-protein kinase DDB_G0291664 (959 aa)    
Predicted Functional Partners:
mpl2
MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (695 aa)
   
  0.931
ptpC
Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130) (990 aa)
     
  0.914
accA
Acetyl-CoA carboxylaseBiotin carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2282 aa)
   
 
  0.872
Rb
Rb-like proteinRetinoblastoma-like protein; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell- cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in l [...] (1312 aa)
     
  0.869
DDB0231196
Probable serine/threonine-protein kinase DDB_G0291516 (965 aa)
     
 
0.865
DDB0215442
Immunoglobulin E-set domain-containing protein (846 aa)
     
        0.860
tgrA3
Immunoglobulin E-set domain-containing protein (1087 aa)
     
        0.857
mpl1
MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development (834 aa)
   
  0.832
DDB0202081
Immunoglobulin E-set domain-containing protein (1038 aa)
     
        0.829
mpl3
MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (856 aa)
     
  0.827
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum, Dictyostelium discoideum
Server load: low (22%) [HD]