STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gtf2h2General transcription factor IIH subunit 2; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (461 aa)    
Predicted Functional Partners:
repD
TFIIH basal transcription factor complex helicase repD subunit; ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex to the core-TFIIH complex (By similarity); Belongs to the helicase family. RAD3/XPD subfamily
   
 0.999
repB
TFIIH basal transcription factor complex helicase repB subunit; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex to the core- TFIIH complex; Belongs to the helicase family. RAD25/XPB subfamily
   
 0.998
gtf2h3
General transcription factor IIH subunit 3; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
   
 0.998
gtf2h4
General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
   
 0.998
gtf2h1
General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
   
 0.997
mnat1
annotation not available
   
 0.997
cdk7
Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
   
 0.991
gtf2b
Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family
   
 0.984
cycH
Putative cyclin-H; May regulate cdk7 involved in transcription regulation and cell cycle progression
   
 0.982
ercc1
DNA excision repair protein ERCC-1; Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair
   
 
 0.980
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: ATCC 11735, D. discoideum, Dictyostelium discoideum, IMI 69094
Server load: low (9%) [HD]