STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrrALeucine-rich repeat protein lrrA; Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis. (510 aa)    
Predicted Functional Partners:
lrlA
Latrophilin receptor-like protein A.
    
 
 0.993
sevA
Severin; Severin blocks the ends of F-actin and causes the fragmentation and depolymerization of actin filaments in a Ca(2+) dependent manner; Belongs to the villin/gelsolin family.
 
 
   0.901
DDB_G0288795
Probable serine/threonine-protein kinase DDB_G0288795.
   
  0.783
pkbA
RAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ.
     
 0.754
gca
Guanylyl cyclase, membrane; Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis.
    
 
 0.515
sgcA
Guanylyl cyclase.
    
 
 0.514
scrA
Protein SCAR; Involved in regulation of actin and microtubule organization. Regulates phagocytosis and macropinocytosis. Belongs to the SCAR/WAVE family.
    
 
 0.488
DDB0205791
RIC1 domain-containing protein.
    
 
 0.471
GxcN
Uncharacterized protein.
      
 0.467
DDB_G0295823
Putative uncharacterized protein DDB_G0295823.
      
 0.450
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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