STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0184085Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (313 aa)    
Predicted Functional Partners:
DDB_G0286969
Von Willebrand factor A domain-containing protein DDB_G0286969.
    
 0.913
eif4g
Eukaryotic translation initiation factor 4 gamma; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
    
 0.913
eif4e
Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family.
  
  
0.912
DDB0205066
Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.
  
  
 
0.907
pirA
Protein pirA; Involved in regulation of actin and microtubule organization.
     
  0.900
DDB0205713
GYF domain-containing protein.
    
 
 0.628
febA
Eukaryotic translation initiation factor 4E-1A-binding protein homolog; Regulates assembly of the eIF4F complex.
    
 0.621
ifdA
IfdA.
   
 
 0.579
eif5
Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity).
     
 0.568
DDB0218641
Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.
   
 
0.561
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.