STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0188339Amino_oxidase domain-containing protein. (464 aa)    
Predicted Functional Partners:
DDB0206422
PWWP domain-containing protein.
    
 
 0.993
fdfT
Squalene synthase.
   
 
 0.644
DDB_G0291852
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages; Belongs to the NDUFAF6 family.
   
 
 0.577
H4a
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.507
H2Bv3
Histone H2B.v3; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
   
 
 0.496
DDB0219750
Uncharacterized protein.
  
 
 0.481
DDB0216403
Heat shock factor (HSF)-type DNA-binding domain-containing protein.
   
  
 0.466
comG
Aldehyde dehydrogenase family 3 comG.
    
 0.463
argC
N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family.
      
 0.461
DDB0203824
VWFA domain-containing protein.
   
 
 0.453
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.