STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0188241Uncharacterized protein. (123 aa)    
Predicted Functional Partners:
cyp51
Probable lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).
   
 
 0.869
erg2
Protein erg2 homolog; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity); Belongs to the ERG2 family.
   
 
 0.847
cas1
Cycloartenol synthase; Converts oxidosqualene to cycloartenol (in vitro); Belongs to the terpene cyclase/mutase family.
   
 
 0.845
fdfT
Squalene synthase.
   
 
 0.829
DDB0167227
Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.
   
  
 0.697
DDB_G0291852
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages; Belongs to the NDUFAF6 family.
   
 
 0.658
DDB0205936
Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.
   
 
 0.634
DDB_G0270946
Putative methylsterol monooxygenase DDB_G0270946.
   
 
 0.634
DDB_G0269788
Putative methylsterol monooxygenase DDB_G0269788.
   
 
 0.634
erg24
Delta(14)-sterol reductase; Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta- 8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Belongs to the ERG4/ERG24 family.
   
 
 0.588
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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