STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0185467Uncharacterized protein. (518 aa)    
Predicted Functional Partners:
prpf8
Pre-mRNA-processing-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
    
 
 0.994
Eftud2
Tr-type G domain-containing protein.
   
 
 0.945
ascc3l
Activating signal cointegrator 1 complex subunit 3-like; Belongs to the helicase family.
    
 
 0.929
ecd
Protein ecdysoneless homolog; May act as a transcriptional activator.
    
 
 0.897
DDB0190158
Uncharacterized protein.
   
 
 0.820
helB2
ATP-dependent RNA helicase ddx23; Probable ATP-dependent RNA helicase which may be involved in mRNA splicing; Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
   
 
 0.814
DDB0189482
Uncharacterized protein.
   
 
 0.776
DDB0206296
HIT-type domain-containing protein.
    
 
 0.662
ascc3
Activating signal cointegrator 1 complex subunit 3.
    
 
 0.660
snrnp40
U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.
   
 
 0.604
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.