STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0205075Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (367 aa)    
Predicted Functional Partners:
smc5
Structural maintenance of chromosome protein.
   
 0.997
smc6
Structural maintenance of chromosomes protein 6; Core component of the smc5-smc6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the smc1-smc3 cohesin complex to double-strand breaks (By similarity).
   
 0.997
DDB0205664
Uncharacterized protein.
   
 0.997
DDB0188371
SP-RING-type domain-containing protein.
    
 0.988
DDB0186138
MAGE domain-containing protein.
   
 0.887
smc3
Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. Involved in chromosome cohesion during the cell cycle and in DNA repair it also regulates DNA replication. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosomes movem [...]
   
 0.838
smc1
Structural maintenance of chromosomes protein.
   
 0.786
DDB_G0293566
Probable GH family 25 lysozyme 5; Belongs to the glycosyl hydrolase 25 family.
   
 
 0.784
DDB0202975
Chalcone_isomerase domain-containing protein.
   
 
 0.784
DDB_G0274181
Probable GH family 25 lysozyme 2; Belongs to the glycosyl hydrolase 25 family.
   
 
 0.784
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.