STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mef2ATranscription factor mef2A; Transcription factor that regulates cell differentiation during development. Seems to negatively regulate prestalk gene expression and positively regulate prespore gene expression. (1048 aa)    
Predicted Functional Partners:
ddx20
Probable ATP-dependent RNA helicase ddx20; Probable ATP-binding RNA helicase which may be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DDX20 subfamily.
      
 0.700
timm50
Mitochondrial import inner membrane translocase subunit tim50; Component of the mitochondrial import inner membrane translocase that mediates the translocation of transit peptide- containing proteins across the mitochondrial inner membrane.
      
 0.700
hdaD
Type-2 histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
   
 
 0.620
phbB
Prohibitin-2; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
   
 
 0.494
atp5f1b
ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...]
      
 0.483
pspD
Spore coat protein SP87; May contribute to the structure of the coat at the interface between the middle, cellulosic layer and the outer, electron-dense, proteinaceous layer.
   
 
 0.475
hbx3
Homeobox protein 3; Putative transcription factor.
      
 0.466
DG1054
EGF-like domain-containing protein.
    
 
 0.465
DG1124
DBC1 domain-containing protein.
      
 0.459
pks32
Probable polyketide synthase 32; Probable polyketide synthase.
      
 0.445
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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